CMap Candidate Details

Structure:
CMap ID: C20448
Pert ID: BRD-K56699285
Compound Name: metergoline
Targets: HTR1A; HTR2A
MoA: Serotonin receptor antagonist; Dopamine receptor agonist
SMILES: CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@H]2[C@H]1Cc1cn(C)c3cccc2c13
InchiKey: WZHJKEUHNJHDLS-QTGUNEKASA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1589 BRD-K56699285 HA1E 10 uM 24 h 0.23 0.96 0.07 0.33 1.18 0.97
1926 BRD-K56699285 HCC515 10 uM 24 h 0.26 1.07 0.2 0.31 1.09 0.67
2486 BRD-K56699285 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41794 BRD-K56699285 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41953 BRD-K56699285 A549 10 uM 24 h 0.21 0.88 0.01 0.0 0.0 0.0
42400 BRD-K56699285 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42719 BRD-K56699285 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43019 BRD-K56699285 HT29 10 uM 6 h 0.0 0.0 0.0 0.28 1.0 0.42
43584 BRD-K56699285 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43888 BRD-K56699285 PHH 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.23 1.28
44144 BRD-K56699285 SKB 10 uM 24 h 0.0 0.0 0.0 0.35 1.23 1.24
51229 BRD-K56699285 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.59
51486 BRD-K56699285 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).