CMap Candidate Details

Structure:
CMap ID: C02046
Pert ID: BRD-A83859836
Compound Name: tropisetron
Targets: HTR3A
MoA: Serotonin receptor antagonist
SMILES: CN1C2CCC1CC(C2)OC(=O)c3c[nH]c4ccccc34
InchiKey: ZNRGQMMCGHDTEI-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2819 BRD-A83859836 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.33
3325 BRD-A83859836 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3590 BRD-A83859836 PC3 10 uM 6 h -0.25 -1.06 0.25 0.0 0.0 0.0
3932 BRD-A83859836 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.97 0.45
39074 BRD-A83859836 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39287 BRD-A83859836 A549 10 uM 24 h 0.0 0.0 0.0 -0.21 -0.7 0.03
39921 BRD-A83859836 HEPG2 10 uM 6 h -0.27 -1.14 0.42 -0.23 -0.76 0.07
40206 BRD-A83859836 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40581 BRD-A83859836 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40724 BRD-A83859836 NEU 10 uM 24 h 0.26 1.07 0.19 0.0 0.0 0.0
41026 BRD-A83859836 NPC 10 uM 24 h 0.31 1.3 0.73 -0.3 -1.02 0.6
41349 BRD-A83859836 SKB 10 uM 24 h -0.26 -1.09 0.32 -0.34 -1.16 1.11
100356 BRD-A83859836 U2OS 10 uM 6 h 0.18 0.75 0.0 0.21 0.74 0.03
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).