CMap Candidate Details

Structure:
CMap ID: C20493
Pert ID: BRD-K56844688
Compound Name: epirubicin
Targets: TOP2A
MoA: Topoisomerase inhibitor
SMILES: COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@@H](O[C@H]5C[C@H](N)[C@@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
InchiKey: AOJJSUZBOXZQNB-SQGPBGNMSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
123791 BRD-K56844688 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123833 BRD-K56844688 A549 10 uM 24 h -0.31 -1.31 0.82 0.0 0.0 0.0
123893 BRD-K56844688 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123961 BRD-K56844688 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123993 BRD-K56844688 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124047 BRD-K56844688 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124092 BRD-K56844688 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124151 BRD-K56844688 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124175 BRD-K56844688 THP1 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124228 BRD-K56844688 YAPC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132162 BRD-K56844688 HA1E 0.01 uM 24 h 0.23 0.94 0.06 -0.26 -0.87 0.23
132191 BRD-K56844688 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132273 BRD-K56844688 MDAMB231 0.74 uM 24 h 0.18 0.76 0.0 0.25 0.89 0.21
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).