CMap Candidate Details

Structure:
CMap ID: C20495
Pert ID: BRD-K56851771
Compound Name: enzalutamide
Targets: AR
MoA: Androgen receptor antagonist
SMILES: CNC(=O)c1ccc(cc1F)N1C(=S)N(C(=O)C1(C)C)c1ccc(C#N)c(c1)C(F)(F)F
InchiKey: WXCXUHSOUPDCQV-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9213 BRD-K56851771 A549 0.25 uM 6 h -0.31 -1.29 0.79 -0.28 -0.96 0.42
9758 BRD-K56851771 H1299 0.25 uM 6 h 0.0 0.0 0.0 -0.33 -1.11 0.91
10230 BRD-K56851771 HCC515 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10543 BRD-K56851771 HCT116 0.25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10807 BRD-K56851771 HEPG2 0.25 uM 6 h 0.0 0.0 0.0 -0.22 -0.73 0.04
11787 BRD-K56851771 NCIH508 0.25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12080 BRD-K56851771 NCIH596 0.25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13082 BRD-K56851771 THP1 0.25 uM 6 h -0.26 -1.1 0.35 0.0 0.0 0.0
13305 BRD-K56851771 U937 0.25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
88484 BRD-K56851771 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.21 -0.7 0.03
123580 BRD-K56851771 HEK293 0.04 uM 24 h 0.18 0.75 0.0 0.0 0.0 0.0
123621 BRD-K56851771 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123655 BRD-K56851771 HT29 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123697 BRD-K56851771 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131987 BRD-K56851771 A375 0.01 uM 24 h 0.0 0.0 0.0 0.33 1.16 0.9
132015 BRD-K56851771 HA1E 0.03 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
132088 BRD-K56851771 MCF??7.00 0.08 uM 24 h -0.28 -1.18 0.5 -0.27 -0.9 0.28
132119 BRD-K56851771 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132143 BRD-K56851771 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).