CMap Candidate Details

Structure:
CMap ID: C02058
Pert ID: BRD-A84205515
Compound Name: estriol
Targets: ESR1; ESR2
MoA: Estrogen receptor agonist
SMILES: COc1ccc2C3CCC4(C)C(O)[C@H](O)CC4C3CCc2c1
InchiKey: UHQGCIIQUZBJAE-JZJKZLICSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2821 BRD-A84205515 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.2 -0.66 0.01
3121 BRD-A84205515 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3454 BRD-A84205515 PC3 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.08
3933 BRD-A84205515 VCAP 10 uM 6 h 0.23 0.94 0.06 -0.28 -0.93 0.34
44265 BRD-A84205515 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44652 BRD-A84205515 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44790 BRD-A84205515 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45111 BRD-A84205515 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45382 BRD-A84205515 HT29 10 uM 6 h 0.0 0.0 0.0 0.33 1.17 0.92
45752 BRD-A84205515 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.21 -0.69 0.03
45910 BRD-A84205515 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46227 BRD-A84205515 PHH 10 uM 24 h -0.28 -1.18 0.51 -0.29 -0.97 0.45
46542 BRD-A84205515 SKB 10 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).