CMap Candidate Details

Structure:
CMap ID: C20589
Pert ID: BRD-K57080016
Compound Name: selumetinib
Targets: MAP2K1
MoA: MEK inhibitor
SMILES: Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(cc12)C(=O)NOCCO
InchiKey: CYOHGALHFOKKQC-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
478 BRD-K57080016 BJAB 2.5 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
524 BRD-K57080016 HBL1 0.66 uM 24 h 0.0 0.0 0.0 0.33 1.16 0.91
588 BRD-K57080016 K562 10 uM 4 h 0.0 0.0 0.0 0.33 1.17 0.95
616 BRD-K57080016 KMS34 10 uM 24 h 0.23 0.96 0.08 0.26 0.92 0.26
661 BRD-K57080016 MINO 0.04 uM 24 h 0.26 1.09 0.23 0.28 0.98 0.38
708 BRD-K57080016 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
781 BRD-K57080016 OCILY19 2.5 uM 4 h 0.0 0.0 0.0 0.37 1.31 1.59
822 BRD-K57080016 OCILY3 2.5 uM 4 h 0.22 0.92 0.04 0.0 0.0 0.0
849 BRD-K57080016 SKMEL5 2.5 uM 24 h 0.0 0.0 0.0 0.34 1.19 1.03
953 BRD-K57080016 TMD8 10 uM 4 h 0.25 1.02 0.13 0.0 0.0 0.0
9454 BRD-K57080016 AGS 80 uM 6 h 0.0 0.0 0.0 0.32 1.13 0.84
9760 BRD-K57080016 H1299 80 uM 6 h 0.0 0.0 0.0 0.38 1.33 1.72
10131 BRD-K57080016 HCC515 80 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10544 BRD-K57080016 HCT116 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11519 BRD-K57080016 NCIH2073 80 uM 6 h 0.0 0.0 0.0 0.4 1.43 2.2
11789 BRD-K57080016 NCIH508 80 uM 6 h -0.23 -0.96 0.1 0.0 0.0 0.0
12082 BRD-K57080016 NCIH596 80 uM 6 h 0.0 0.0 0.0 0.34 1.21 1.14
12820 BRD-K57080016 SW480 80 uM 6 h 0.0 0.0 0.0 0.4 1.43 2.2
13307 BRD-K57080016 U937 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
88564 BRD-K57080016 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.22 1.25
91082 BRD-K57080016 HUH7 1.11 uM 72 h 0.0 0.0 0.0 -0.26 -0.89 0.27
92419 BRD-K57080016 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92479 BRD-K57080016 BT20 3.33 uM 24 h 0.0 0.0 0.0 0.39 1.37 2.09
92543 BRD-K57080016 HME1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92610 BRD-K57080016 HS578T 3.33 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92699 BRD-K57080016 LNCAP 0.12 uM 3 h 0.21 0.9 0.02 -0.29 -0.98 0.47
92748 BRD-K57080016 MCF10A 0.04 uM 3 h 0.0 0.0 0.0 -0.34 -1.13 0.99
92792 BRD-K57080016 MDAMB231 1.11 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92815 BRD-K57080016 PC3 0.04 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.81
92837 BRD-K57080016 SKBR3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95521 BRD-K57080016 A549 1.11 uM 48 h 0.17 0.69 0.0 0.0 0.0 0.0
95559 BRD-K57080016 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95645 BRD-K57080016 U2OS 10 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.92
95858 BRD-K57080016 NPC 6.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
117400 BRD-K57080016 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117487 BRD-K57080016 HEPG2 0.04 uM 24 h 0.0 0.0 0.0 0.4 1.41 2.19
123895 BRD-K57080016 HEK293 1.11 uM 24 h 0.0 0.0 0.0 -0.4 -1.35 2.01
123995 BRD-K57080016 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124177 BRD-K57080016 THP1 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124230 BRD-K57080016 YAPC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132193 BRD-K57080016 HELA 0.08 uM 24 h -0.27 -1.11 0.36 0.18 0.64 0.0
132225 BRD-K57080016 HT29 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).