CMap Candidate Details
Structure:
CMap ID: | C20608 |
Pert ID: | BRD-K57169635 |
Compound Name: | dacomitinib |
Targets: | EGFR; ERBB2; ERBB4 |
MoA: | EGFR inhibitor |
SMILES: | COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=CCN1CCCCC1 |
InchiKey: | LVXJQMNHJWSHET-AATRIKPKSA-N |
Compound Aliases: | -- |
Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
---|---|---|---|---|---|---|---|---|---|---|
92928 | BRD-K57169635 | ASC | 10 uM | 24 h | -0.18 | -0.76 | 0.0 | 0.0 | 0.0 | 0.0 |
92991 | BRD-K57169635 | CD34 | 10 uM | 24 h | 0.27 | 1.14 | 0.32 | 0.0 | 0.0 | 0.0 |
93037 | BRD-K57169635 | HA1E | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
93079 | BRD-K57169635 | HEK293 | 10 uM | 24 h | 0.3 | 1.25 | 0.56 | 0.35 | 1.22 | 1.15 |
93167 | BRD-K57169635 | HEPG2 | 10 uM | 24 h | 0.19 | 0.81 | 0.0 | 0.0 | 0.0 | 0.0 |
93216 | BRD-K57169635 | HUVEC | 10 uM | 24 h | 0.23 | 0.95 | 0.06 | -0.33 | -1.12 | 0.94 |
93354 | BRD-K57169635 | MDAMB231 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.33 | 1.17 | 0.92 |
93416 | BRD-K57169635 | NPC | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.3 | -1.02 | 0.61 |
93481 | BRD-K57169635 | SKL | 10 uM | 24 h | 0.23 | 0.98 | 0.09 | 0.32 | 1.13 | 0.82 |
93579 | BRD-K57169635 | YAPC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.3 | 1.07 | 0.62 |
123794 | BRD-K57169635 | A375 | 3.33 uM | 24 h | 0.31 | 1.28 | 0.61 | 0.0 | 0.0 | 0.0 |
123836 | BRD-K57169635 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.34 | 1.21 | 1.13 |
123942 | BRD-K57169635 | HELA | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.31 | 1.11 | 0.74 |
123963 | BRD-K57169635 | HT29 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
123998 | BRD-K57169635 | JURKAT | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
124051 | BRD-K57169635 | MCF10A | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
124095 | BRD-K57169635 | MCF??7.00 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.27 | 0.96 | 0.34 |
124153 | BRD-K57169635 | PC3 | 10 uM | 24 h | -0.21 | -0.88 | 0.03 | 0.29 | 1.03 | 0.51 |
124180 | BRD-K57169635 | THP1 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |