CMap Candidate Details

Structure:
CMap ID: C20632
Pert ID: BRD-K57222227
Compound Name: indometacin
Targets: PTGDR2; PPARG; PTGS1; PTGS2
MoA: Cyclooxygenase inhibitor
SMILES: COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)O)c2c1
InchiKey: CGIGDMFJXJATDK-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
7184 BRD-K57222227 A549 10 uM 6 h -0.21 -0.86 0.02 0.0 0.0 0.0
8711 BRD-K57222227 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53035 BRD-K57222227 HEPG2 100 uM 48 h 0.0 0.0 0.0 0.22 0.78 0.06
53117 BRD-K57222227 MCF10A 30 uM 24 h -0.29 -1.21 0.58 0.0 0.0 0.0
90802 BRD-K57222227 HPTEC 320 uM 6 h 0.18 0.74 0.0 -0.26 -0.88 0.25
91154 BRD-K57222227 HUH7 10 uM 72 h -0.34 -1.42 1.43 0.0 0.0 0.0
99690 BRD-K57222227 U2OS 15 uM 6 h -0.24 -1.0 0.14 0.0 0.0 0.0
115414 BRD-K57222227 HCC515 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115516 BRD-K57222227 HT29 10 uM 24 h 0.24 1.01 0.12 0.33 1.16 0.9
123561 BRD-K57222227 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123721 BRD-K57222227 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123740 BRD-K57222227 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123760 BRD-K57222227 YAPC 10 uM 24 h 0.22 0.91 0.03 0.0 0.0 0.0
131972 BRD-K57222227 A375 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132005 BRD-K57222227 HA1E 0.25 uM 24 h 0.29 1.22 0.48 0.21 0.75 0.04
132030 BRD-K57222227 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).