CMap Candidate Details

Structure:
CMap ID: C20735
Pert ID: BRD-K57569181
Compound Name: pentoxifylline
Targets: ADORA2A; PDE4A; PDE4B; TNF; PDE5A
MoA: Phosphodiesterase inhibitor
SMILES: CC(=O)CCCCn1c(=O)n(C)c2ncn(C)c2c1=O
InchiKey: BYPFEZZEUUWMEJ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5096 BRD-K57569181 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.95 0.41
37702 BRD-K57569181 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37926 BRD-K57569181 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38523 BRD-K57569181 NPC 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
38752 BRD-K57569181 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
51317 BRD-K57569181 MCF??7.00 10 uM 6 h 0.24 0.98 0.09 0.0 0.0 0.0
91336 BRD-K57569181 HUH7 12 uM 72 h -0.22 -0.93 0.07 0.31 1.08 0.65
95535 BRD-K57569181 A549 1.11 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95674 BRD-K57569181 U2OS 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
96736 BRD-K57569181 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119898 BRD-K57569181 HCC515 0.01 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
119922 BRD-K57569181 PC3 0.01 uM 6 h 0.0 0.0 0.0 -0.28 -0.95 0.39
123871 BRD-K57569181 HA1E 0.04 uM 24 h -0.21 -0.86 0.02 0.25 0.87 0.17
123899 BRD-K57569181 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124000 BRD-K57569181 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 -0.41 -1.39 2.02
124053 BRD-K57569181 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.72
124123 BRD-K57569181 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124182 BRD-K57569181 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124234 BRD-K57569181 YAPC 0.37 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.56
132195 BRD-K57569181 HELA 0.03 uM 24 h -0.21 -0.87 0.02 0.0 0.0 0.0
132227 BRD-K57569181 HT29 0.03 uM 24 h 0.24 1.01 0.12 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).