CMap Candidate Details

Structure:
CMap ID: C02074
Pert ID: BRD-A84575140
Compound Name: pimobendan
Targets: PDE3A
MoA: Calcium sensitizer; Phosphodiesterase inhibitor
SMILES: COc1ccc(cc1)-c1nc2cc(ccc2[nH]1)C1=NNC(=O)CC1C
InchiKey: GLBJJMFZWDBELO-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125565 BRD-A84575140 A375 10 uM 24 h 0.3 1.26 0.56 -0.22 -0.73 0.05
125638 BRD-A84575140 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125668 BRD-A84575140 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125714 BRD-A84575140 HUVEC 10 uM 24 h -0.26 -1.1 0.33 -0.31 -1.04 0.66
125764 BRD-A84575140 JURKAT 10 uM 24 h 0.21 0.88 0.02 0.0 0.0 0.0
125820 BRD-A84575140 MCF??7.00 10 uM 24 h 0.21 0.89 0.02 0.0 0.0 0.0
125913 BRD-A84575140 YAPC 3.33 uM 24 h 0.28 1.15 0.33 -0.3 -1.0 0.53
133658 BRD-A84575140 A549 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133686 BRD-A84575140 HA1E 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133787 BRD-A84575140 HT29 0.03 uM 24 h 0.0 0.0 0.0 0.37 1.3 1.54
133844 BRD-A84575140 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133902 BRD-A84575140 MDAMB231 0.74 uM 24 h 0.19 0.79 0.0 0.23 0.8 0.08
133933 BRD-A84575140 PC3 0.08 uM 24 h 0.28 1.15 0.32 0.35 1.22 1.18
133964 BRD-A84575140 THP1 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).