CMap Candidate Details

Structure:
CMap ID: C20784
Pert ID: BRD-K57764956
Compound Name: cariprazine
Targets: DRD2; DRD3
MoA: Dopamine receptor antagonist
SMILES: CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(Cl)c2Cl)CC1
InchiKey: KPWSJANDNDDRMB-QAQDUYKDSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
123520 BRD-K57764956 A375 0.125 uM 24 h -0.27 -1.12 0.39 0.32 1.12 0.75
123542 BRD-K57764956 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123583 BRD-K57764956 HEK293 0.04 uM 24 h 0.26 1.1 0.24 0.0 0.0 0.0
123657 BRD-K57764956 HT29 1.11 uM 24 h 0.0 0.0 0.0 -0.35 -1.16 1.11
123699 BRD-K57764956 MCF10A 10 uM 24 h 0.24 0.99 0.1 0.0 0.0 0.0
123726 BRD-K57764956 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.06
123769 BRD-K57764956 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132043 BRD-K57764956 HELA 0.03 uM 24 h 0.28 1.16 0.34 0.32 1.12 0.74
132121 BRD-K57764956 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).