CMap Candidate Details

Structure:
CMap ID: C00209
Pert ID: BRD-A08187463
Compound Name: racecadotril
Targets: MME
MoA: Enkephalinase inhibitor
SMILES: CC(=O)SCC(Cc1ccccc1)C(=O)NCC(=O)OCc1ccccc1
InchiKey: ODUOJXZPIYUATO-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4003 BRD-A08187463 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.78
4272 BRD-A08187463 HCC515 10 uM 24 h -0.27 -1.12 0.38 0.29 1.01 0.46
4833 BRD-A08187463 VCAP 10 uM 24 h 0.25 1.04 0.14 0.0 0.0 0.0
37437 BRD-A08187463 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37781 BRD-A08187463 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38291 BRD-A08187463 NPC 10 uM 24 h -0.19 -0.78 0.0 0.0 0.0 0.0
38600 BRD-A08187463 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38816 BRD-A08187463 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91409 BRD-A08187463 HUH7 8 uM 72 h -0.26 -1.08 0.3 0.0 0.0 0.0
121142 BRD-A08187463 A375 0.04 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.05
121178 BRD-A08187463 A549 0.04 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
121246 BRD-A08187463 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121286 BRD-A08187463 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.32 1.14 0.87
121303 BRD-A08187463 PC3 0.125 uM 24 h 0.18 0.77 0.0 0.31 1.1 0.7
129287 BRD-A08187463 HT29 0.25 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.08
129360 BRD-A08187463 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.72
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).