CMap Candidate Details

Structure:
CMap ID: C02106
Pert ID: BRD-A86109770
Compound Name: guggulsterone
Targets: NR3C1; AR; NR3C2; PGR; NR1H4
MoA: IKK inhibitor; FXR antagonist; Cholesterol inhibitor; Estrogen receptor agonist; Pregnane X receptor agonist; Progesterone receptor agonist
SMILES: CC=C1C(=O)CC2C3CCC4=CC(=O)CCC4(C)C3CCC21C
InchiKey: WDXRGPWQVHZTQJ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2824 BRD-A86109770 HA1E 10 uM 24 h 0.3 1.24 0.51 0.0 0.0 0.0
3124 BRD-A86109770 HCC515 10 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.93
3456 BRD-A86109770 PC3 10 uM 24 h 0.0 0.0 0.0 0.33 1.16 0.91
3708 BRD-A86109770 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39076 BRD-A86109770 A375 10 uM 6 h 0.0 0.0 0.0 0.24 0.85 0.15
39415 BRD-A86109770 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39604 BRD-A86109770 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39924 BRD-A86109770 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40209 BRD-A86109770 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40583 BRD-A86109770 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40727 BRD-A86109770 NEU 10 uM 24 h -0.28 -1.15 0.43 0.0 0.0 0.0
41029 BRD-A86109770 NPC 10 uM 24 h 0.26 1.07 0.2 -0.29 -0.99 0.5
41352 BRD-A86109770 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).