CMap Candidate Details

Structure:
CMap ID: C21110
Pert ID: BRD-K58938839
Compound Name: cyclopamine
Targets: SMO
MoA: Smoothened receptor antagonist
SMILES: C[C@@H]1[C@@H]2NC[C@@H](C)C[C@H]2O[C@@]31CC[C@H]4[C@@H]5CC=C6C[C@@H](O)CC[C@]6(C)[C@H]5CC4=C3C
InchiKey: QASFUMOKHFSJGL-LAFRSMQTSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1590 BRD-K58938839 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1927 BRD-K58938839 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2165 BRD-K58938839 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2649 BRD-K58938839 VCAP 10 uM 6 h 0.0 0.0 0.0 0.31 1.09 0.67
41954 BRD-K58938839 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42401 BRD-K58938839 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42720 BRD-K58938839 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43020 BRD-K58938839 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43332 BRD-K58938839 MCF??7.00 10 uM 6 h 0.21 0.89 0.02 0.36 1.28 1.36
43585 BRD-K58938839 NPC 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.86
43889 BRD-K58938839 PHH 10 uM 24 h 0.26 1.08 0.22 0.0 0.0 0.0
44145 BRD-K58938839 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99700 BRD-K58938839 U2OS 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).