CMap Candidate Details

Structure:
CMap ID: C21139
Pert ID: BRD-K59013864
Compound Name: AM-24
Targets: ALOX5
MoA: Lipoxygenase inhibitor
SMILES: Oc1c(I)cc(I)cc1I
InchiKey: VAPDZNUFNKUROY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
123803 BRD-K59013864 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123842 BRD-K59013864 A549 1.11 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.73
123908 BRD-K59013864 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123947 BRD-K59013864 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123968 BRD-K59013864 HT29 10 uM 24 h 0.25 1.05 0.16 0.35 1.24 1.28
124009 BRD-K59013864 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.1
124062 BRD-K59013864 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.63
124130 BRD-K59013864 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124191 BRD-K59013864 THP1 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124243 BRD-K59013864 YAPC 0.04 uM 24 h 0.24 0.98 0.09 -0.39 -1.32 1.71
132169 BRD-K59013864 HA1E 0.74 uM 24 h 0.2 0.84 0.0 0.0 0.0 0.0
132257 BRD-K59013864 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132301 BRD-K59013864 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).