CMap Candidate Details

Structure:
CMap ID: C21161
Pert ID: BRD-K59067695
Compound Name: SU-11274
Targets: MET
MoA: Tyrosine kinase inhibitor; Hepatocyte growth factor receptor inhibitor
SMILES: CN(c1cccc(Cl)c1)S(=O)(=O)c1ccc2NC(=O)C(=Cc3[nH]c(C)c(C(=O)N4CCN(C)CC4)c3C)c2c1
InchiKey: FPYJSJDOHRDAMT-XQNSMLJCSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91817 BRD-K59067695 HS578T 10 uM 6 h -0.26 -1.09 0.33 0.39 1.36 1.95
91844 BRD-K59067695 MCF10A 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91859 BRD-K59067695 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91897 BRD-K59067695 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91967 BRD-K59067695 SKBR3 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
97013 BRD-K59067695 A375 10 uM 24 h 0.0 0.0 0.0 0.41 1.46 2.23
97092 BRD-K59067695 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).