CMap Candidate Details

Structure:
CMap ID: C21206
Pert ID: BRD-K59197931
Compound Name: naproxen
Targets: PTGS1; PTGS2
MoA: Cyclooxygenase inhibitor
SMILES: COc1ccc2cc(ccc2c1)[C@H](C)C(O)=O
InchiKey: CMWTZPSULFXXJA-VIFPVBQESA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
22804 BRD-K59197931 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.08 0.81
23101 BRD-K59197931 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24328 BRD-K59197931 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91156 BRD-K59197931 HUH7 15 uM 72 h -0.2 -0.84 0.01 0.0 0.0 0.0
99702 BRD-K59197931 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
123570 BRD-K59197931 HEK293 0.125 uM 24 h -0.27 -1.13 0.41 -0.31 -1.05 0.7
123646 BRD-K59197931 HT29 1.11 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.47
123687 BRD-K59197931 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131978 BRD-K59197931 A375 0.08 uM 24 h 0.0 0.0 0.0 -0.43 -1.44 15.35
132010 BRD-K59197931 HA1E 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132035 BRD-K59197931 HELA 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132079 BRD-K59197931 MCF??7.00 0.01 uM 24 h 0.27 1.13 0.29 0.0 0.0 0.0
132110 BRD-K59197931 PC3 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132138 BRD-K59197931 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).