CMap Candidate Details

Structure:
CMap ID: C21214
Pert ID: BRD-K59222562
Compound Name: BRD-K59222562
Targets: CLK1; DYRK1A; CLK4; DYRK1B
MoA: DYRK inhibitor
SMILES: CN(Cc1cccs1)c1ncnc2ccc(cc12)-c1ccc2OCOc2c1
InchiKey: LXDHFJUOCGKVAV-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
16279 BRD-K59222562 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
16722 BRD-K59222562 A549 10 uM 6 h 0.0 0.0 0.0 -0.21 -0.72 0.04
17050 BRD-K59222562 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
17388 BRD-K59222562 HEPG2 10 uM 6 h -0.2 -0.83 0.0 -0.23 -0.79 0.11
17727 BRD-K59222562 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
18008 BRD-K59222562 MCF??7.00 10 uM 24 h 0.32 1.33 0.84 0.0 0.0 0.0
18471 BRD-K59222562 PC3 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.02 0.6
18802 BRD-K59222562 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
96031 BRD-K59222562 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).