CMap Candidate Details

Structure:
CMap ID: C02122
Pert ID: BRD-A87137733
Compound Name: GSK-690693
Targets: AKT3; AKT1; AKT2; PRKCQ
MoA: Akt inhibitor
SMILES: CCn1c(nc2c(ncc(OCC3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N
InchiKey: KGPGFQWBCSZGEL-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91861 BRD-A87137733 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91988 BRD-A87137733 A375 10 uM 24 h 0.24 0.99 0.1 0.27 0.96 0.33
92039 BRD-A87137733 BT20 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92064 BRD-A87137733 HA1E 10 uM 24 h -0.19 -0.79 0.0 -0.3 -1.01 0.58
92094 BRD-A87137733 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92133 BRD-A87137733 HS578T 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92187 BRD-A87137733 HT29 3.33 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.69
92212 BRD-A87137733 MCF10A 1.11 uM 24 h 0.23 0.98 0.09 0.0 0.0 0.0
92307 BRD-A87137733 MDAMB231 10 uM 3 h 0.26 1.1 0.24 0.0 0.0 0.0
92336 BRD-A87137733 PC3 10 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.63
92364 BRD-A87137733 SKBR3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).