CMap Candidate Details

Structure:
CMap ID: C21231
Pert ID: BRD-K59273480
Compound Name: propentofylline
Targets: PDE1A
MoA: Phosphodiesterase inhibitor; Adenosine reuptake inhibitor
SMILES: CCCn1cnc2n(C)c(=O)n(CCCCC(C)=O)c(=O)c12
InchiKey: RBQOQRRFDPXAGN-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6898 BRD-K59273480 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7698 BRD-K59273480 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.03 0.62
8713 BRD-K59273480 VCAP 10 uM 24 h -0.22 -0.91 0.05 0.29 1.03 0.49
99703 BRD-K59273480 U2OS 10 uM 6 h 0.0 0.0 0.0 0.24 0.83 0.12
123846 BRD-K59273480 A549 3.33 uM 24 h -0.2 -0.85 0.01 0.23 0.82 0.1
123912 BRD-K59273480 HEK293 10 uM 24 h 0.0 0.0 0.0 0.28 1.01 0.44
123951 BRD-K59273480 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124013 BRD-K59273480 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124066 BRD-K59273480 MCF10A 0.125 uM 24 h -0.23 -0.95 0.09 0.0 0.0 0.0
124133 BRD-K59273480 MDAMB231 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.7
124195 BRD-K59273480 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.39
124247 BRD-K59273480 YAPC 1.11 uM 24 h 0.19 0.79 0.0 0.0 0.0 0.0
132171 BRD-K59273480 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132236 BRD-K59273480 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132260 BRD-K59273480 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132304 BRD-K59273480 PC3 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).