CMap Candidate Details

Structure:
CMap ID: C21247
Pert ID: BRD-K59332007
Compound Name: linopirdine
Targets: KCNQ2; KCNQ3
MoA: Potassium channel blocker
SMILES: O=C1N(c2ccccc2C1(Cc1ccncc1)Cc1ccncc1)c1ccccc1
InchiKey: YEJCDKJIEMIWRQ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6899 BRD-K59332007 A375 10 uM 6 h -0.22 -0.9 0.05 -0.34 -1.14 1.01
7473 BRD-K59332007 HA1E 10 uM 6 h 0.0 0.0 0.0 0.27 0.95 0.32
22311 BRD-K59332007 A549 10 uM 6 h -0.35 -1.44 1.43 0.0 0.0 0.0
22805 BRD-K59332007 HCC515 10 uM 6 h -0.23 -0.95 0.09 -0.35 -1.17 1.11
23102 BRD-K59332007 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24329 BRD-K59332007 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
123913 BRD-K59332007 HEK293 0.125 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
124014 BRD-K59332007 JURKAT 0.37 uM 24 h 0.25 1.06 0.18 -0.37 -1.25 1.35
124067 BRD-K59332007 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124134 BRD-K59332007 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124196 BRD-K59332007 THP1 0.125 uM 24 h 0.23 0.98 0.09 0.29 1.01 0.44
124248 BRD-K59332007 YAPC 0.37 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
132201 BRD-K59332007 HELA 0.08 uM 24 h 0.0 0.0 0.0 0.32 1.14 0.85
132237 BRD-K59332007 HT29 0.08 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.14
132261 BRD-K59332007 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132305 BRD-K59332007 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.15
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).