CMap Candidate Details

Structure:
CMap ID: C21256
Pert ID: BRD-K59369769
Compound Name: tozasertib
Targets: BCR; AURKA; AURKC; AURKB; FLT3; ABL1; JAK2
MoA: JAK inhibitor; FLT3 inhibitor; Aurora kinase inhibitor; Abl kinase inhibitor
SMILES: CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1
InchiKey: GCIKSSRWRFVXBI-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
41 BRD-K59369769 BJAB 10 uM 4 h 0.0 0.0 0.0 0.36 1.29 1.49
79 BRD-K59369769 HBL1 10 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.79
143 BRD-K59369769 K562 2.5 uM 4 h -0.23 -0.95 0.09 0.0 0.0 0.0
162 BRD-K59369769 KMS34 2.5 uM 24 h -0.21 -0.88 0.03 -0.38 -1.29 1.53
205 BRD-K59369769 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
243 BRD-K59369769 OCILY10 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
303 BRD-K59369769 OCILY19 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
321 BRD-K59369769 OCILY3 10 uM 24 h 0.25 1.04 0.14 0.0 0.0 0.0
361 BRD-K59369769 SKMEL5 10 uM 24 h -0.22 -0.92 0.06 0.29 1.01 0.45
415 BRD-K59369769 THP1 10 uM 4 h 0.0 0.0 0.0 0.36 1.26 1.29
435 BRD-K59369769 TMD8 10 uM 24 h 0.23 0.98 0.09 0.0 0.0 0.0
1299 BRD-K59369769 MCF??7.00 10 uM 6 h -0.23 -0.96 0.1 0.0 0.0 0.0
1313 BRD-K59369769 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24014 BRD-K59369769 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
30492 BRD-K59369769 ASC 10 uM 24 h -0.18 -0.74 0.0 0.0 0.0 0.0
31393 BRD-K59369769 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32204 BRD-K59369769 NEU 10 uM 24 h 0.24 0.98 0.09 0.0 0.0 0.0
32472 BRD-K59369769 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33074 BRD-K59369769 SKB 10 uM 24 h 0.0 0.0 0.0 0.32 1.14 0.85
90326 BRD-K59369769 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91517 BRD-K59369769 BT20 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91979 BRD-K59369769 A375 0.37 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.63
92054 BRD-K59369769 HA1E 10 uM 24 h 0.22 0.9 0.02 0.0 0.0 0.0
92085 BRD-K59369769 HCC515 3.33 uM 24 h 0.0 0.0 0.0 -0.45 -1.52 15.35
92123 BRD-K59369769 HS578T 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92205 BRD-K59369769 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92280 BRD-K59369769 MDAMB231 3.33 uM 24 h 0.23 0.95 0.07 -0.24 -0.8 0.11
92384 BRD-K59369769 SKBR3 1.11 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
118896 BRD-K59369769 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119211 BRD-K59369769 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123916 BRD-K59369769 HEK293 10 uM 24 h 0.25 1.03 0.13 -0.37 -1.25 1.35
124018 BRD-K59369769 JURKAT 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.71
124252 BRD-K59369769 YAPC 10 uM 24 h 0.0 0.0 0.0 0.41 1.45 2.22
132204 BRD-K59369769 HELA 0.74 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.74
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).