CMap Candidate Details

Structure:
CMap ID: C02127
Pert ID: BRD-A87445400
Compound Name: yohimbine
Targets: ADRA2A; ADRA2B; ADRA2C; HTR1A; HTR1B; HTR1D; HTR2B
MoA: Adrenergic receptor antagonist
SMILES: COC(=O)C1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12
InchiKey: BLGXFZZNTVWLAY-AMZRAFDVSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5283 BRD-A87445400 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5556 BRD-A87445400 HCC515 10 uM 24 h 0.0 0.0 0.0 0.2 0.71 0.02
6251 BRD-A87445400 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6321 BRD-A87445400 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
37108 BRD-A87445400 A375 10 uM 6 h 0.21 0.87 0.01 -0.32 -1.08 0.78
37257 BRD-A87445400 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37560 BRD-A87445400 ASC 10 uM 24 h 0.0 0.0 0.0 -0.43 -1.44 15.35
37860 BRD-A87445400 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38042 BRD-A87445400 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38170 BRD-A87445400 MCF??7.00 10 uM 24 h 0.27 1.12 0.26 0.0 0.0 0.0
38401 BRD-A87445400 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38670 BRD-A87445400 PHH 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.22
38893 BRD-A87445400 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).