CMap Candidate Details

Structure:
CMap ID: C21282
Pert ID: BRD-K59456551
Compound Name: methotrexate
Targets: DHFR
MoA: Dihydrofolate reductase inhibitor
SMILES: CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
InchiKey: FBOZXECLQNJBKD-ZDUSSCGKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
24460 BRD-K59456551 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24591 BRD-K59456551 A549 10 uM 24 h 0.0 0.0 0.0 0.18 0.63 0.0
24795 BRD-K59456551 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24928 BRD-K59456551 HT29 10 uM 6 h -0.21 -0.89 0.03 0.32 1.15 0.88
25397 BRD-K59456551 VCAP 10 uM 24 h -0.22 -0.92 0.06 -0.28 -0.93 0.35
51231 BRD-K59456551 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.44
51492 BRD-K59456551 PC3 10 uM 24 h 0.0 0.0 0.0 -0.4 -1.35 2.02
52925 BRD-K59456551 HEPG2 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53321 BRD-K59456551 MCF10A 12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).