CMap Candidate Details

Structure:
CMap ID: C21329
Pert ID: BRD-K59574735
Compound Name: ubenimex
Targets: LTA4H; RNPEP
MoA: Leukotriene inhibitor
SMILES: CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
InchiKey: VGGGPCQERPFHOB-RDBSUJKOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3239 BRD-K59574735 HCC515 10 uM 24 h 0.26 1.06 0.19 0.35 1.25 1.29
3838 BRD-K59574735 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41955 BRD-K59574735 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42403 BRD-K59574735 ASC 10 uM 24 h 0.0 0.0 0.0 0.32 1.15 0.89
42721 BRD-K59574735 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43587 BRD-K59574735 NPC 10 uM 24 h -0.23 -0.96 0.1 -0.37 -1.23 1.28
43890 BRD-K59574735 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44146 BRD-K59574735 SKB 10 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
99707 BRD-K59574735 U2OS 15 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
123539 BRD-K59574735 HA1E 10 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
123576 BRD-K59574735 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123620 BRD-K59574735 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123651 BRD-K59574735 HT29 0.04 uM 24 h 0.0 0.0 0.0 -0.46 -1.53 15.35
123693 BRD-K59574735 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131983 BRD-K59574735 A375 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132084 BRD-K59574735 MCF??7.00 2.22 uM 24 h -0.29 -1.19 0.53 0.0 0.0 0.0
132116 BRD-K59574735 PC3 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132140 BRD-K59574735 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).