CMap Candidate Details

Structure:
CMap ID: C21369
Pert ID: BRD-K59715032
Compound Name: pasireotide
Targets: SSTR1; SSTR2; SSTR3; SSTR5
MoA: Somatostatin receptor agonist
SMILES: NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O)OC(=O)NCCN)c1ccccc1
InchiKey: VMZMNAABQBOLAK-DBILLSOUSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
123813 BRD-K59715032 A375 10 uM 24 h 0.17 0.72 0.0 0.0 0.0 0.0
123853 BRD-K59715032 A549 10 uM 24 h -0.25 -1.04 0.21 0.0 0.0 0.0
123876 BRD-K59715032 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123922 BRD-K59715032 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124024 BRD-K59715032 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124075 BRD-K59715032 MCF10A 0.125 uM 24 h 0.24 0.99 0.1 -0.35 -1.18 1.15
124104 BRD-K59715032 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.47
124205 BRD-K59715032 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124258 BRD-K59715032 YAPC 0.04 uM 24 h -0.22 -0.93 0.07 0.33 1.18 0.98
132209 BRD-K59715032 HELA 0.01 uM 24 h 0.23 0.95 0.07 0.35 1.23 1.19
132243 BRD-K59715032 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132280 BRD-K59715032 MDAMB231 2.22 uM 24 h -0.23 -0.95 0.09 0.31 1.08 0.66
132311 BRD-K59715032 PC3 0.03 uM 24 h 0.19 0.77 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).