CMap Candidate Details

Structure:
CMap ID: C21472
Pert ID: BRD-K60038276
Compound Name: irbesartan
Targets: AGTR1
MoA: Angiotensin receptor antagonist
SMILES: CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
InchiKey: YOSHYTLCDANDAN-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5656 BRD-K60038276 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24592 BRD-K60038276 A549 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.81
25034 BRD-K60038276 MCF??7.00 10 uM 24 h 0.18 0.75 0.0 0.0 0.0 0.0
25255 BRD-K60038276 PC3 10 uM 6 h 0.0 0.0 0.0 0.28 1.01 0.44
25399 BRD-K60038276 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37706 BRD-K60038276 ASC 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.12
37929 BRD-K60038276 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38527 BRD-K60038276 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38982 BRD-K60038276 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121721 BRD-K60038276 A375 10 uM 24 h 0.21 0.89 0.02 0.0 0.0 0.0
121762 BRD-K60038276 HELA 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.58
121868 BRD-K60038276 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129791 BRD-K60038276 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129826 BRD-K60038276 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129893 BRD-K60038276 HT29 0.74 uM 24 h 0.24 1.0 0.11 0.0 0.0 0.0
129915 BRD-K60038276 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.86
129953 BRD-K60038276 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130037 BRD-K60038276 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130109 BRD-K60038276 THP1 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).