CMap Candidate Details

Structure:
CMap ID: C00215
Pert ID: BRD-A08545410
Compound Name: doxycycline
Targets: MMP8
MoA: Metalloproteinase inhibitor
SMILES: C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(=O)C(C(N)=O)C(=O)[C@@]3(O)C(=O)C2C(=O)c2c(O)cccc12
InchiKey: VXVNYCRICCVPTD-MULYGRJNSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91269 BRD-A08545410 HUH7 8 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
95339 BRD-A08545410 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95353 BRD-A08545410 MCF??7.00 10 uM 24 h 0.24 1.01 0.12 0.26 0.9 0.23
95470 BRD-A08545410 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
96886 BRD-A08545410 A375 3.33 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.5
121216 BRD-A08545410 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121265 BRD-A08545410 HELA 3.33 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
121276 BRD-A08545410 HT29 0.125 uM 24 h -0.18 -0.75 0.0 0.0 0.0 0.0
121306 BRD-A08545410 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129364 BRD-A08545410 YAPC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).