CMap Candidate Details

Structure:
CMap ID: C02150
Pert ID: BRD-A88774919
Compound Name: doxycycline
Targets: MMP8
MoA: Metalloproteinase inhibitor
SMILES: CC1C2C(O)C3C(N(C)C)C(=O)C(C(N)=O)C(=O)C3(O)C(=O)C2C(=O)c2c(O)cccc12
InchiKey: VXVNYCRICCVPTD-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
49787 BRD-A88774919 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
49965 BRD-A88774919 A549 10 uM 6 h 0.25 1.03 0.13 -0.21 -0.71 0.04
50129 BRD-A88774919 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50318 BRD-A88774919 HCC515 10 uM 6 h 0.0 0.0 0.0 0.35 1.23 1.23
50482 BRD-A88774919 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50644 BRD-A88774919 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
50820 BRD-A88774919 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
50996 BRD-A88774919 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).