CMap Candidate Details

Structure:
CMap ID: C21538
Pert ID: BRD-K60219430
Compound Name: serdemetan
Targets: MDM2
MoA: MDM inhibitor
SMILES: C(Cc1c[nH]c2ccccc12)Nc1cccc(Nc2ccncc2)c1
InchiKey: JCKLHFMOFAYQHE-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9054 BRD-K60219430 A375 10 uM 6 h 0.0 0.0 0.0 0.3 1.07 0.64
9214 BRD-K60219430 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9460 BRD-K60219430 AGS 10 uM 6 h -0.23 -0.94 0.08 0.0 0.0 0.0
9766 BRD-K60219430 H1299 10 uM 6 h -0.32 -1.33 0.89 0.0 0.0 0.0
9970 BRD-K60219430 HA1E 10 uM 24 h 0.21 0.9 0.02 0.35 1.23 1.23
10221 BRD-K60219430 HCC515 10 uM 24 h 0.22 0.91 0.04 0.0 0.0 0.0
10811 BRD-K60219430 HEPG2 10 uM 6 h -0.22 -0.9 0.05 0.0 0.0 0.0
10989 BRD-K60219430 HT29 10 uM 24 h -0.19 -0.8 0.0 0.25 0.9 0.22
11285 BRD-K60219430 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11526 BRD-K60219430 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11796 BRD-K60219430 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12088 BRD-K60219430 NCIH596 10 uM 6 h -0.28 -1.19 0.53 -0.35 -1.19 1.15
12347 BRD-K60219430 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.29 1.04 0.56
12545 BRD-K60219430 PC3 10 uM 24 h 0.18 0.74 0.0 0.0 0.0 0.0
12825 BRD-K60219430 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13314 BRD-K60219430 U937 10 uM 6 h -0.19 -0.79 0.0 0.45 1.58 2.35
13645 BRD-K60219430 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91819 BRD-K60219430 HS578T 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.96 0.43
91916 BRD-K60219430 MDAMB231 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.09 0.82
91942 BRD-K60219430 SKBR3 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94497 BRD-K60219430 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94573 BRD-K60219430 CD34 10 uM 24 h 0.18 0.74 0.0 0.0 0.0 0.0
94661 BRD-K60219430 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94709 BRD-K60219430 HELA 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.2
94768 BRD-K60219430 HME1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94860 BRD-K60219430 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94911 BRD-K60219430 JURKAT 3.33 uM 24 h -0.31 -1.3 0.82 0.0 0.0 0.0
94955 BRD-K60219430 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95038 BRD-K60219430 NEU 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95064 BRD-K60219430 NPC 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.05
95187 BRD-K60219430 SHSY5Y 10 uM 24 h 0.27 1.11 0.25 0.0 0.0 0.0
95246 BRD-K60219430 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95295 BRD-K60219430 THP1 1.11 uM 24 h 0.27 1.13 0.28 0.0 0.0 0.0
97262 BRD-K60219430 HAP1 0.66 uM 24 h 0.25 1.06 0.19 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).