CMap Candidate Details

Structure:
CMap ID: C21541
Pert ID: BRD-K60237333
Compound Name: niacin
Targets: HCAR2; HCAR3
MoA: Vitamin B; NAD precursor with lipid lowering effects
SMILES: OC(=O)c1cccnc1
InchiKey: PVNIIMVLHYAWGP-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
53406 BRD-K60237333 HEPG2 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53597 BRD-K60237333 HUH7 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
53678 BRD-K60237333 PHH 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123812 BRD-K60237333 A375 0.04 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
123852 BRD-K60237333 A549 0.125 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
123921 BRD-K60237333 HEK293 1.11 uM 24 h 0.25 1.04 0.15 0.0 0.0 0.0
124023 BRD-K60237333 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124074 BRD-K60237333 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.54
124140 BRD-K60237333 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.9
124156 BRD-K60237333 PC3 3.33 uM 24 h -0.27 -1.12 0.38 0.0 0.0 0.0
124204 BRD-K60237333 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124257 BRD-K60237333 YAPC 1.11 uM 24 h 0.21 0.86 0.01 0.0 0.0 0.0
132178 BRD-K60237333 HA1E 0.01 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.9
132208 BRD-K60237333 HELA 2.22 uM 24 h 0.27 1.14 0.32 0.0 0.0 0.0
132242 BRD-K60237333 HT29 0.03 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.1
132265 BRD-K60237333 MCF??7.00 0.01 uM 24 h -0.23 -0.96 0.1 -0.27 -0.9 0.28
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).