CMap Candidate Details

Structure:
CMap ID: C02158
Pert ID: BRD-A89164055
Compound Name: sorbinil
Targets: AKR1B1
MoA: Aldose reductase inhibitor
SMILES: Fc1ccc2OCCC3(NC(=O)NC3=O)c2c1
InchiKey: LXANPKRCLVQAOG-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127730 BRD-A89164055 A375 10 uM 24 h -0.27 -1.13 0.41 0.0 0.0 0.0
127772 BRD-A89164055 A549 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127812 BRD-A89164055 HA1E 3.33 uM 24 h 0.22 0.9 0.02 0.0 0.0 0.0
127850 BRD-A89164055 HEK293 0.125 uM 24 h 0.0 0.0 0.0 -0.28 -0.96 0.42
127924 BRD-A89164055 HUVEC 3.33 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.03
127978 BRD-A89164055 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128021 BRD-A89164055 MCF??7.00 0.04 uM 24 h -0.2 -0.85 0.01 0.0 0.0 0.0
128069 BRD-A89164055 YAPC 0.04 uM 24 h 0.24 0.99 0.09 0.26 0.92 0.25
135551 BRD-A89164055 HELA 0.08 uM 24 h 0.21 0.87 0.01 -0.21 -0.72 0.04
135600 BRD-A89164055 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135642 BRD-A89164055 JURKAT 0.03 uM 24 h -0.26 -1.09 0.31 0.27 0.96 0.34
135713 BRD-A89164055 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).