CMap Candidate Details

Structure:
CMap ID: C21605
Pert ID: BRD-K60460488
Compound Name: nelfinavir
Targets: CYP1A2; CYP3A7; CYP2B6; CYP2C19; CYP2C9; CYP2D6; CYP3A4
MoA: HIV protease inhibitor
SMILES: Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@@H]2CCCC[C@@H]2C[C@H]1C(=O)NC(C)(C)C
InchiKey: QAGYKUNXZHXKMR-BBDMRMKHSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33611 BRD-K60460488 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
33917 BRD-K60460488 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34135 BRD-K60460488 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34387 BRD-K60460488 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34649 BRD-K60460488 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34916 BRD-K60460488 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.95 0.4
35167 BRD-K60460488 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35329 BRD-K60460488 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.4 -1.36 2.02
35589 BRD-K60460488 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35808 BRD-K60460488 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35971 BRD-K60460488 PC3 10 uM 24 h -0.17 -0.72 0.0 0.0 0.0 0.0
36294 BRD-K60460488 PHH 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.03 0.62
36595 BRD-K60460488 SKB 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.82
36980 BRD-K60460488 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.11 0.9
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).