CMap Candidate Details

Structure:
CMap ID: C21610
Pert ID: BRD-K60476892
Compound Name: YC-1
Targets: GUCY1A2; HIF1A
MoA: Guanylyl cyclase activator
SMILES: OCc1ccc(o1)c2nn(Cc3ccccc3)c4ccccc24
InchiKey: OQQVFCKUDYMWGV-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2911 BRD-K60476892 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3243 BRD-K60476892 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
3531 BRD-K60476892 PC3 10 uM 24 h 0.3 1.26 0.58 0.0 0.0 0.0
3843 BRD-K60476892 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41803 BRD-K60476892 A375 10 uM 6 h -0.28 -1.15 0.44 0.0 0.0 0.0
41957 BRD-K60476892 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42411 BRD-K60476892 ASC 10 uM 24 h 0.0 0.0 0.0 0.2 0.72 0.02
42728 BRD-K60476892 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43029 BRD-K60476892 HT29 10 uM 6 h 0.0 0.0 0.0 0.35 1.25 1.29
43336 BRD-K60476892 MCF??7.00 10 uM 6 h 0.16 0.67 0.0 0.0 0.0 0.0
43592 BRD-K60476892 NPC 10 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.56
44152 BRD-K60476892 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53598 BRD-K60476892 HUH7 4 uM 6 h 0.0 0.0 0.0 0.24 0.87 0.17
53680 BRD-K60476892 PHH 15 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.24
99714 BRD-K60476892 U2OS 15 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).