CMap Candidate Details

Structure:
CMap ID: C21615
Pert ID: BRD-K60487568
Compound Name: SU-4312
Targets: KDR
MoA: PDGFR inhibitor; VEGFR inhibitor; Tyrosine kinase inhibitor
SMILES: CN(C)c1ccc(C=C2C(=O)Nc3ccccc23)cc1
InchiKey: UAKWLVYMKBWHMX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3043 BRD-K60487568 HA1E 10 uM 6 h -0.24 -1.0 0.15 0.0 0.0 0.0
3385 BRD-K60487568 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3637 BRD-K60487568 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3976 BRD-K60487568 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.02 0.61
39150 BRD-K60487568 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39467 BRD-K60487568 A549 10 uM 6 h -0.28 -1.15 0.43 0.0 0.0 0.0
39723 BRD-K60487568 ASC 10 uM 24 h 0.0 0.0 0.0 0.33 1.15 0.89
40022 BRD-K60487568 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40295 BRD-K60487568 HT29 10 uM 6 h -0.2 -0.83 0.0 0.19 0.66 0.01
40487 BRD-K60487568 MCF??7.00 10 uM 24 h -0.2 -0.82 0.0 -0.31 -1.03 0.63
40836 BRD-K60487568 NEU 10 uM 24 h 0.0 0.0 0.0 0.36 1.28 1.37
41142 BRD-K60487568 NPC 10 uM 24 h 0.29 1.2 0.42 0.28 0.98 0.37
41479 BRD-K60487568 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).