CMap Candidate Details

Structure:
CMap ID: C21659
Pert ID: BRD-K60640630
Compound Name: mometasone
Targets: NR3C1
MoA: Glucocorticoid receptor agonist
SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c5ccco5)C(=O)CCl
InchiKey: WOFMFGQZHJDGCX-ZULDAHANSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2912 BRD-K60640630 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.11
3245 BRD-K60640630 HCC515 10 uM 24 h 0.22 0.93 0.05 -0.26 -0.89 0.26
3532 BRD-K60640630 PC3 10 uM 24 h 0.16 0.66 0.0 0.32 1.14 0.87
3844 BRD-K60640630 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41804 BRD-K60640630 A375 10 uM 6 h 0.21 0.88 0.02 0.0 0.0 0.0
42116 BRD-K60640630 A549 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.22 1.24
42413 BRD-K60640630 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42730 BRD-K60640630 HEPG2 10 uM 6 h -0.21 -0.87 0.02 -0.31 -1.05 0.71
43030 BRD-K60640630 HT29 10 uM 6 h 0.21 0.88 0.02 0.0 0.0 0.0
43211 BRD-K60640630 MCF??7.00 10 uM 24 h -0.25 -1.06 0.25 -0.36 -1.21 1.23
43594 BRD-K60640630 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43898 BRD-K60640630 PHH 10 uM 24 h 0.22 0.9 0.02 -0.22 -0.75 0.06
44154 BRD-K60640630 SKB 10 uM 24 h 0.0 0.0 0.0 -0.44 -1.48 15.35
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).