CMap Candidate Details

Structure:
CMap ID: C21708
Pert ID: BRD-K60762818
Compound Name: desipramine
Targets: SLC6A2; SLC6A4
MoA: Tricyclic antidepressant
SMILES: CNCCCN1c2ccccc2CCc2ccccc12
InchiKey: HCYAFALTSJYZDH-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5347 BRD-K60762818 HA1E 10 uM 24 h 0.19 0.77 0.0 0.35 1.25 1.29
5793 BRD-K60762818 HCC515 10 uM 6 h 0.24 1.0 0.1 0.31 1.11 0.72
6576 BRD-K60762818 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41805 BRD-K60762818 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42117 BRD-K60762818 A549 10 uM 6 h 0.0 0.0 0.0 0.23 0.81 0.09
42414 BRD-K60762818 ASC 10 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.78
42731 BRD-K60762818 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43031 BRD-K60762818 HT29 10 uM 6 h 0.22 0.93 0.05 0.47 1.67 2.47
43212 BRD-K60762818 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.67
43595 BRD-K60762818 NPC 10 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.31
43899 BRD-K60762818 PHH 10 uM 24 h 0.32 1.32 0.79 0.33 1.16 0.9
44155 BRD-K60762818 SKB 10 uM 24 h -0.2 -0.81 0.0 -0.24 -0.81 0.13
50851 BRD-K60762818 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).