CMap Candidate Details

Structure:
CMap ID: C21710
Pert ID: BRD-K60770992
Compound Name: pergolide
Targets: ADRA2A; ADRA2B; ADRA2C; DRD1; DRD2; DRD3; DRD4; DRD5; HTR1A; HTR1B; HTR1D; HTR2A; HTR2B; HTR2C
MoA: Dopamine receptor agonist
SMILES: CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13
InchiKey: YEHCICAEULNIGD-MZMPZRCHSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5348 BRD-K60770992 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5658 BRD-K60770992 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5936 BRD-K60770992 HEPG2 10 uM 6 h -0.31 -1.27 0.74 -0.21 -0.7 0.03
6206 BRD-K60770992 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24463 BRD-K60770992 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24931 BRD-K60770992 HT29 10 uM 6 h -0.23 -0.95 0.09 0.0 0.0 0.0
25400 BRD-K60770992 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
37406 BRD-K60770992 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37707 BRD-K60770992 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38528 BRD-K60770992 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38756 BRD-K60770992 PHH 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.02
51345 BRD-K60770992 MCF??7.00 10 uM 6 h 0.27 1.14 0.31 -0.35 -1.18 1.14
90952 BRD-K60770992 HUH7 10 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).