CMap Candidate Details

Structure:
CMap ID: C21758
Pert ID: BRD-K60866521
Compound Name: idelalisib
Targets: PIK3CD; PIK3CG
MoA: PI3K inhibitor
SMILES: CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(F)c2c(=O)n1-c1ccccc1
InchiKey: IFSDAJWBUCMOAH-HNNXBMFYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
517 BRD-K60866521 BJAB 10 uM 24 h 0.24 1.02 0.12 0.0 0.0 0.0
548 BRD-K60866521 HBL1 2.5 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.34
610 BRD-K60866521 K562 0.01 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
655 BRD-K60866521 KMS34 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
701 BRD-K60866521 MINO 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
749 BRD-K60866521 NALM6 0.66 uM 24 h 0.0 0.0 0.0 -0.27 -0.89 0.27
777 BRD-K60866521 OCILY19 10 uM 24 h 0.23 0.96 0.08 0.0 0.0 0.0
891 BRD-K60866521 SKMEL5 2.5 uM 24 h 0.0 0.0 0.0 -0.41 -1.39 2.02
977 BRD-K60866521 TMD8 0.125 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
87588 BRD-K60866521 OCILY10 0.125 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.17
87689 BRD-K60866521 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.33
88570 BRD-K60866521 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
92965 BRD-K60866521 ASC 10 uM 24 h 0.27 1.13 0.29 0.0 0.0 0.0
93022 BRD-K60866521 CD34 1.11 uM 24 h 0.0 0.0 0.0 0.39 1.38 2.17
93107 BRD-K60866521 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.34 1.2 1.13
93248 BRD-K60866521 HUVEC 10 uM 24 h 0.22 0.91 0.03 -0.37 -1.24 1.35
93298 BRD-K60866521 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93334 BRD-K60866521 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
93376 BRD-K60866521 MDAMB231 1.11 uM 24 h 0.18 0.74 0.0 0.0 0.0 0.0
93407 BRD-K60866521 NPC 10 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
93521 BRD-K60866521 SKL 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93562 BRD-K60866521 THP1 1.11 uM 24 h -0.26 -1.08 0.31 -0.31 -1.05 0.7
93602 BRD-K60866521 YAPC 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95423 BRD-K60866521 U2OS 0.12 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
117046 BRD-K60866521 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117086 BRD-K60866521 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.79
117127 BRD-K60866521 HCC515 10 uM 24 h 0.24 1.02 0.13 0.0 0.0 0.0
117175 BRD-K60866521 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123744 BRD-K60866521 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131985 BRD-K60866521 A375 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132039 BRD-K60866521 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132060 BRD-K60866521 HT29 0.03 uM 24 h 0.0 0.0 0.0 -0.34 -1.16 1.11
132085 BRD-K60866521 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.2 0.71 0.02
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).