CMap Candidate Details

Structure:
CMap ID: C21794
Pert ID: BRD-K60997853
Compound Name: PHA-848125
Targets: CDK2; CDK4; NTRK1; CDK1
MoA: CDK inhibitor; Growth factor receptor inhibitor
SMILES: CNC(=O)c1nn(C)c-2c1C(C)(C)Cc1cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc-21
InchiKey: RXZMYLDMFYNEIM-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90876 BRD-K60997853 MCF10A 3.33 uM 3 h 0.0 0.0 0.0 -0.39 -1.32 1.71
97308 BRD-K60997853 HAP1 0.66 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.58
123581 BRD-K60997853 HEK293 1.11 uM 24 h 0.0 0.0 0.0 -0.43 -1.44 15.35
123656 BRD-K60997853 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131988 BRD-K60997853 A375 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132016 BRD-K60997853 HA1E 2.22 uM 24 h 0.25 1.05 0.16 0.0 0.0 0.0
132042 BRD-K60997853 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132089 BRD-K60997853 MCF??7.00 0.03 uM 24 h -0.19 -0.78 0.0 -0.23 -0.78 0.09
132120 BRD-K60997853 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132144 BRD-K60997853 YAPC 0.74 uM 24 h -0.23 -0.94 0.08 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).