CMap Candidate Details

Structure:
CMap ID: C02189
Pert ID: BRD-A90451247
Compound Name: KU-60019
Targets: ATM
MoA: ATM kinase inhibitor
SMILES: CC1CN(CC(=O)Nc2ccc3Sc4c(Cc3c2)cccc4-c2cc(=O)cc(o2)N2CCOCC2)CC(C)O1
InchiKey: SCELLOWTHJGVIC-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91790 BRD-A90451247 HS578T 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91837 BRD-A90451247 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.27
91866 BRD-A90451247 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91908 BRD-A90451247 MDAMB231 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.11 0.91
91926 BRD-A90451247 SKBR3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93606 BRD-A90451247 A549 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93637 BRD-A90451247 ASC 10 uM 24 h 0.26 1.07 0.2 0.28 1.0 0.42
93694 BRD-A90451247 CD34 10 uM 24 h 0.27 1.11 0.26 0.33 1.16 0.91
93745 BRD-A90451247 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93780 BRD-A90451247 HCC515 10 uM 24 h -0.18 -0.74 0.0 0.0 0.0 0.0
93820 BRD-A90451247 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
93871 BRD-A90451247 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93911 BRD-A90451247 HEPG2 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93980 BRD-A90451247 HUVEC 3.33 uM 24 h 0.28 1.18 0.39 -0.36 -1.22 1.24
94007 BRD-A90451247 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94087 BRD-A90451247 NEU 10 uM 24 h -0.2 -0.85 0.01 0.0 0.0 0.0
94150 BRD-A90451247 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94186 BRD-A90451247 PC3 10 uM 24 h -0.3 -1.25 0.68 0.0 0.0 0.0
94217 BRD-A90451247 SHSY5Y 3.33 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.31
94270 BRD-A90451247 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94320 BRD-A90451247 THP1 10 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.15
94365 BRD-A90451247 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).