CMap Candidate Details

Structure:
CMap ID: C21931
Pert ID: BRD-K61397605
Compound Name: romidepsin
Targets: HDAC1; HDAC2
MoA: HDAC inhibitor
SMILES: CC=C1/NC(=O)[C@H]2CSSCCC=C[C@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@@H](NC1=O)C(C)C
InchiKey: OHRURASPPZQGQM-GCCNXGTGSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95344 BRD-K61397605 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95387 BRD-K61397605 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123821 BRD-K61397605 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123862 BRD-K61397605 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123931 BRD-K61397605 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123956 BRD-K61397605 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123977 BRD-K61397605 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124033 BRD-K61397605 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124084 BRD-K61397605 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124161 BRD-K61397605 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124214 BRD-K61397605 THP1 1.11 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
124267 BRD-K61397605 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132183 BRD-K61397605 HA1E 2.22 uM 24 h 0.27 1.14 0.32 0.0 0.0 0.0
132282 BRD-K61397605 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).