CMap Candidate Details

Structure:
CMap ID: C21932
Pert ID: BRD-K61401890
Compound Name: deguelin
Targets: AKT1
MoA: NADH-ubiquinone oxidoreductase (Complex I) inhibitor
SMILES: COc1cc2OC[C@H]3Oc4c5C=CC(C)(C)Oc5ccc4C(=O)[C@H]3c2cc1OC
InchiKey: ORDAZKGHSNRHTD-UXHICEINSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4944 BRD-K61401890 VCAP 10 uM 24 h -0.21 -0.88 0.03 0.0 0.0 0.0
37708 BRD-K61401890 ASC 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.37
37930 BRD-K61401890 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38529 BRD-K61401890 NPC 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.6
38757 BRD-K61401890 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38983 BRD-K61401890 SKB 10 uM 24 h 0.25 1.06 0.19 0.0 0.0 0.0
115976 BRD-K61401890 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116017 BRD-K61401890 A549 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116056 BRD-K61401890 HA1E 10 uM 24 h 0.24 0.99 0.1 0.0 0.0 0.0
116098 BRD-K61401890 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
116189 BRD-K61401890 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116227 BRD-K61401890 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116266 BRD-K61401890 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).