CMap Candidate Details

Structure:
CMap ID: C21959
Pert ID: BRD-K61480498
Compound Name: epoxycholesterol
Targets: NR1H3; NR1H2
MoA: LXR agonist
SMILES: C[C@H](CC[C@@H]1OC1(C)C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
InchiKey: OSENKJZWYQXHBN-XVYZBDJZSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33817 BRD-K61480498 A549 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
34139 BRD-K61480498 ASC 10 uM 24 h -0.22 -0.92 0.06 -0.37 -1.26 1.36
34390 BRD-K61480498 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34652 BRD-K61480498 HCC515 10 uM 6 h 0.22 0.92 0.04 -0.41 -1.39 2.02
34920 BRD-K61480498 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.24 0.84 0.12
35171 BRD-K61480498 HT29 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.04 0.66
35331 BRD-K61480498 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
35974 BRD-K61480498 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36298 BRD-K61480498 PHH 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.25
36599 BRD-K61480498 SKB 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.86 0.22
36844 BRD-K61480498 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99067 BRD-K61480498 NEU 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.8 0.12
99167 BRD-K61480498 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).