CMap Candidate Details

Structure:
CMap ID: C02200
Pert ID: BRD-A90799790
Compound Name: isradipine
Targets: CACNA1C; CACNA1D; CACNA1F; CACNA1S; CACNA2D1
MoA: Calcium channel blocker
SMILES: COC(=O)C1=C(C)NC(C)=C(C1c1cccc2nonc12)C(=O)OC(C)C
InchiKey: HMJIYCCIJYRONP-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1469 BRD-A90799790 NPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7605 BRD-A90799790 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
8633 BRD-A90799790 VCAP 10 uM 24 h -0.23 -0.96 0.1 0.29 1.02 0.48
127342 BRD-A90799790 A375 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.16 1.1
127384 BRD-A90799790 A549 1.11 uM 24 h -0.26 -1.08 0.29 0.0 0.0 0.0
127415 BRD-A90799790 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.2 0.7 0.01
127458 BRD-A90799790 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127503 BRD-A90799790 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127597 BRD-A90799790 PC3 10 uM 24 h 0.0 0.0 0.0 0.15 0.52 0.0
127639 BRD-A90799790 THP1 0.37 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.38
127673 BRD-A90799790 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135392 BRD-A90799790 HT29 0.03 uM 24 h -0.3 -1.24 0.64 0.0 0.0 0.0
135432 BRD-A90799790 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135465 BRD-A90799790 MCF??7.00 2.22 uM 24 h -0.26 -1.1 0.34 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).