CMap Candidate Details

Structure:
CMap ID: C22070
Pert ID: BRD-K61829047
Compound Name: 7b-cis
Targets: XPO1
MoA: Exportin antagonist
SMILES: CCOC(=O)C=C/n1nnc(n1)-c1cccc(Cl)c1
InchiKey: AICKZRPQDLFSPA-SREVYHEPSA-N
Compound Aliases: 7B-CIS

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9218 BRD-K61829047 A549 10 uM 6 h 0.0 0.0 0.0 0.32 1.12 0.76
9466 BRD-K61829047 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9773 BRD-K61829047 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9950 BRD-K61829047 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10204 BRD-K61829047 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.09
10556 BRD-K61829047 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10816 BRD-K61829047 HEPG2 10 uM 6 h 0.18 0.77 0.0 0.0 0.0 0.0
11095 BRD-K61829047 HT29 10 uM 6 h 0.23 0.94 0.06 0.0 0.0 0.0
11288 BRD-K61829047 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11532 BRD-K61829047 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.23 0.82 0.1
11801 BRD-K61829047 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12095 BRD-K61829047 NCIH596 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.86 0.21
12354 BRD-K61829047 NOMO1 10 uM 6 h -0.29 -1.2 0.55 0.0 0.0 0.0
12618 BRD-K61829047 PC3 10 uM 6 h 0.0 0.0 0.0 0.33 1.17 0.93
12831 BRD-K61829047 SW480 10 uM 6 h -0.32 -1.33 0.9 0.0 0.0 0.0
13051 BRD-K61829047 THP1 10 uM 6 h -0.22 -0.92 0.06 0.33 1.17 0.95
13319 BRD-K61829047 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13489 BRD-K61829047 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96845 BRD-K61829047 A375 3.33 uM 24 h 0.2 0.84 0.0 -0.34 -1.14 1.03
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).