CMap Candidate Details

Structure:
CMap ID: C02216
Pert ID: BRD-A91877226
Compound Name: capecitabine
Targets: TYMS
MoA: DNA synthesis inhibitor; Thymidylate synthase inhibitor
SMILES: CCCCCOC(=O)Nc1nc(=O)n(cc1F)C1O[C@H](C)[C@@H](O)[C@H]1O
InchiKey: GAGWJHPBXLXJQN-LXGADPQPSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127746 BRD-A91877226 A375 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.26
127791 BRD-A91877226 A549 0.125 uM 24 h 0.0 0.0 0.0 0.4 1.41 2.18
127871 BRD-A91877226 HEK293 10 uM 24 h 0.22 0.94 0.05 -0.23 -0.76 0.07
127945 BRD-A91877226 HUVEC 0.04 uM 24 h 0.21 0.89 0.02 0.0 0.0 0.0
127998 BRD-A91877226 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128080 BRD-A91877226 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.97
135528 BRD-A91877226 HA1E 0.03 uM 24 h -0.25 -1.02 0.19 -0.26 -0.87 0.23
135572 BRD-A91877226 HELA 0.01 uM 24 h -0.2 -0.82 0.0 -0.27 -0.91 0.31
135616 BRD-A91877226 HT29 0.74 uM 24 h 0.0 0.0 0.0 -0.34 -1.16 1.1
135663 BRD-A91877226 JURKAT 2.22 uM 24 h 0.2 0.83 0.0 0.0 0.0 0.0
135698 BRD-A91877226 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 -0.27 -0.89 0.27
135721 BRD-A91877226 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.22 0.78 0.07
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).