CMap Candidate Details

Structure:
CMap ID: C02219
Pert ID: BRD-A91992993
Compound Name: siguazodan
Targets: PDE3A
MoA: Phosphodiesterase inhibitor
SMILES: CNC(=Nc1ccc(cc1)C2=NNC(=O)CC2C)NC#N
InchiKey: NUHPODZZKHQQET-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6859 BRD-A91992993 A375 10 uM 6 h 0.18 0.77 0.0 0.0 0.0 0.0
6966 BRD-A91992993 A549 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
7279 BRD-A91992993 HA1E 10 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.32
7607 BRD-A91992993 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.38 -1.27 1.44
7821 BRD-A91992993 HT29 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.26
8068 BRD-A91992993 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.19 0.66 0.01
8486 BRD-A91992993 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
8789 BRD-A91992993 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.09 0.83
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).