CMap Candidate Details

Structure:
CMap ID: C22194
Pert ID: BRD-K62221994
Compound Name: T-98475
Targets: GNRHR
MoA: Gonadotropin releasing factor hormone receptor antagonist
SMILES: CC(C)OC(=O)c1cn(Cc2c(F)cccc2F)c3sc(c(CN(C)Cc4ccccc4)c3c1=O)c5ccc(NC(=O)C(C)C)cc5
InchiKey: RANJJVIMTOIWIN-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1593 BRD-K62221994 HA1E 10 uM 24 h 0.0 0.0 0.0 0.32 1.13 0.85
1933 BRD-K62221994 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2173 BRD-K62221994 PC3 10 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.23
2470 BRD-K62221994 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41809 BRD-K62221994 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41960 BRD-K62221994 A549 10 uM 24 h 0.0 0.0 0.0 0.39 1.38 2.16
42419 BRD-K62221994 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42735 BRD-K62221994 HEPG2 10 uM 6 h -0.18 -0.76 0.0 0.41 1.44 2.21
43036 BRD-K62221994 HT29 10 uM 6 h 0.0 0.0 0.0 0.35 1.24 1.26
43215 BRD-K62221994 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43601 BRD-K62221994 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44161 BRD-K62221994 SKB 10 uM 24 h 0.21 0.88 0.01 0.0 0.0 0.0
99302 BRD-K62221994 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).