CMap Candidate Details

Structure:
CMap ID: C22236
Pert ID: BRD-K62353524
Compound Name: DY-131
Targets: ESR2; ESRRG
MoA: Estrogen receptor agonist; Estrogen-related receptor agonist
SMILES: CCN(CC)c1ccc(C=NNC(=O)c2ccc(O)cc2)cc1
InchiKey: WLKOCYWYAWBGKY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1764 BRD-K62353524 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
1934 BRD-K62353524 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.09
2236 BRD-K62353524 PC3 10 uM 24 h -0.21 -0.88 0.03 0.0 0.0 0.0
2552 BRD-K62353524 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41811 BRD-K62353524 A375 10 uM 6 h -0.19 -0.79 0.0 0.0 0.0 0.0
41962 BRD-K62353524 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42422 BRD-K62353524 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42738 BRD-K62353524 HEPG2 10 uM 6 h 0.25 1.03 0.13 0.0 0.0 0.0
43038 BRD-K62353524 HT29 10 uM 6 h 0.0 0.0 0.0 0.27 0.96 0.33
43217 BRD-K62353524 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43603 BRD-K62353524 NPC 10 uM 24 h -0.21 -0.87 0.02 0.0 0.0 0.0
43905 BRD-K62353524 PHH 10 uM 24 h 0.27 1.13 0.28 -0.23 -0.77 0.08
99307 BRD-K62353524 U2OS 10 uM 6 h -0.26 -1.08 0.3 0.27 0.97 0.35
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).